European Journal of Medicinal Chemistry p. 471 - 477 (1994)
Update date:2022-07-29
Topics: Synthesis Inhibitory activity Derivatives Acetic acid Antioxidant Properties Aldose reductase Pyridazine
Coudert
Albuisson
Boire
Duroux
Bastide
Couquelet
N-Acetic acid derivatives of 4-carboxy-6-arylpyridazin-3-ones were synthesized for the dual purpose of inhibiting aldose reductase and exhibiting antioxidant properties. All the prepared compounds showed a significant in vitro aldose reductase inhibitory
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