Synthesis of pyridazine acetic acid derivatives possessing aldose reductase inhibitory activity and antioxidant properties

DOI: 10.1016/0223-5234(94)90074-4

Source and publish data:

European Journal of Medicinal Chemistry p. 471 - 477 (1994)

Update date:2022-07-29

Topics: Synthesis Inhibitory activity Derivatives Acetic acid Antioxidant Properties Aldose reductase Pyridazine

Authors:

Coudert Coudert

Albuisson

Boire Boire

Duroux Duroux

Bastide Bastide

Couquelet

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Article abstract of DOI:10.1016/0223-5234(94)90074-4

N-Acetic acid derivatives of 4-carboxy-6-arylpyridazin-3-ones were synthesized for the dual purpose of inhibiting aldose reductase and exhibiting antioxidant properties. All the prepared compounds showed a significant in vitro aldose reductase inhibitory

Full text of DOI:10.1016/0223-5234(94)90074-4

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Product name:6-(4-Fluoro-phenyl)-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl ester

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