Synthesis of pyridazine acetic acid derivatives possessing aldose reductase inhibitory activity and antioxidant properties

Article abstract of DOI:10.1016/0223-5234(94)90074-4

N-Acetic acid derivatives of 4-carboxy-6-arylpyridazin-3-ones were synthesized for the dual purpose of inhibiting aldose reductase and exhibiting antioxidant properties. All the prepared compounds showed a significant in vitro aldose reductase inhibitory