Asymmetric synthesis of isoindoline and isoquinoline derivatives using nickel(0)-catalyzed [2 + 2 + 2] cocyclization

Article abstract of DOI:10.1021/jo00100a003

A nickel(0)-catalyzed asymmetric [2 + 2 + 2] cocyclization has been realized for the first time, giving the isoindoline 16a in 73% ee (52% yield) and the isoquinoline 17b in 54% ee (62% yield), respectively.