Asymmetric synthesis of isoindoline and isoquinoline derivatives using nickel(0)-catalyzed [2 + 2 + 2] cocyclization

DOI: 10.1021/jo00100a003

Source and publish data:

Journal of Organic Chemistry p. 6133 - 6135 (1994)

Update date:2022-07-29

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Authors:

Sato Sato

Nishimata

Mori Mori

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Article abstract of DOI:10.1021/jo00100a003

A nickel(0)-catalyzed asymmetric [2 + 2 + 2] cocyclization has been realized for the first time, giving the isoindoline 16a in 73% ee (52% yield) and the isoquinoline 17b in 54% ee (62% yield), respectively.

Full text of DOI:10.1021/jo00100a003

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