Syntheses of 11α-(3-Carboxypropanoyloxy)-1α,25-dihydroxyvitamin D3 and 11α-(4-Carboxybutanoyloxy)-1α,25-dihydroxyvitamin D3: Novel Haptenic Derivatives of Production of Highly Specific Antibodies to 1α,25-Dihydroxyvitamin D3

DOI: 10.1039/P19940001809

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 1809 - 1816 (1994)

Update date:2022-09-26

Topics:

Authors:

Kobayashi, Norihiro

Kitahori, Junichi

Mano, Hidetoshi

Shimada, Kazutake

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Article abstract of DOI:10.1039/P19940001809

The measurement of serum/plasma levels of 1α,25-dihydroxyvitamin D₃ 1 a is important for the diagnosis influencing vitamin D metabolism.To obtain antibodies to the metabolite 1a which are highly specific and useful for development of immunoassays, two novel haptenic derivatives, 11α-(3-carboxypropanoyloxy)-1α,25-dihydroxyvitamin D₃ 2a and 11α-(4-carboxybutanoyloxy)-1α,25-dihydroxyvitamin D₃ 2b were synthesized each in 19 steps from a suitably protected derivative (3) of 11α,25-dihydroxycholesterol.

Full text of DOI:10.1039/P19940001809

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