Highly diastereoselective alkylation of perhydropyrimidin-4-ones directed toward the synthesis of α-substituted β-amino acids. 2

Article abstract of DOI:10.1021/jo00103a020

The alkylation of several enantiomerically pure perhydropyrimidin-4-ones at C₅ is described. For the methylation reaction, mixtures of 5,6-trans -and cis-disubstituted adducts were obtained with high diastereomeric ratios, whereas only the 5,6-