Design, synthesis and biological evaluation of new 5-nitro benzimidazole derivatives as AT1 antagonists with anti-hypertension activities

DOI: 10.1016/j.bmc.2014.02.008

Source and publish data:

Bioorganic and Medicinal Chemistry p. 2294 - 2302 (2014)

Update date:2022-07-31

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Authors:

Zhu, Weibo

Da, Yajing

Wu, Dan Wu, Dan

Zheng, Huiling

Zhu, Linfeng

Wang, Li

Yan, Yijia

Chen, Zhilong

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Article abstract of DOI:10.1016/j.bmc.2014.02.008

The design, synthesis, in vitro and in vivo evaluation of 5-nitro benzimidazole with 1,4-disubsituted or 1,5-disubsituted indole derivatives as novel angiotensin II receptor antagonist is outlined. Radioligand binding assays showed that 2-(4-((2-butyl-5-n

Full text of DOI:10.1016/j.bmc.2014.02.008

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