Synthesis of 10-(hydroxymethyl)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid, a potent new analogue of DDATHF (Lometrexol)

DOI: 10.1021/jo00102a040

Source and publish data:

Journal of Organic Chemistry p. 7096 - 7098 (1994)

Update date:2022-08-05

Topics: Synthesis Compound Potent Experimental Chemical Analogue

Authors:

Taylor Taylor

Yoon Yoon

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Article abstract of DOI:10.1021/jo00102a040

A synthesis of 10-(hydroxymethyl)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid [as a mixture of four diastereomers] is described. Substantial cytotoxicity was observed for this new analogue of DDATHF (Lometrexol).

Full text of DOI:10.1021/jo00102a040

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