Synthesis of 10-(hydroxymethyl)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid, a potent new analogue of DDATHF (Lometrexol)

DOI: 10.1021/jo00102a040

Source and publish data:

Journal of Organic Chemistry p. 7096 - 7098 (1994)

Update date:2022-08-05

Topics: Synthesis Compound Potent Experimental Chemical Analogue

Authors:

Taylor Taylor

Yoon Yoon

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00102a040

A synthesis of 10-(hydroxymethyl)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid [as a mixture of four diastereomers] is described. Substantial cytotoxicity was observed for this new analogue of DDATHF (Lometrexol).

Full text of DOI:10.1021/jo00102a040

Products guided by the article

Product name:Diethyl N-<4-<1-(tetrahydropyranyl-2'-oxy)-3-(2-(pivaloylamino)-3,4-dihydro-4-oxopyrido<2,3-d>pyrimidin-6-yl)prop-2-en-2-yl>benzoyl>-L-glutamate

Cas No:159680-66-7

R&D Labs maybe for 159680-66-7

Hubei Xinghuo Chemical Co., Ltd.,

Contact:13925817279 13907299441

Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China
Wuhan Jadechem International Trade Co.,Ltd.

website:http://www.jadechem-intl.com

Contact:+86-27-83527060

Address:Room 502,Building C11,Software new city No.8,Huacheng Avenue,East Lake High-tech development zone,Wuhan,Hubei,China
WEIFANG RICHEM INTERNATIONAL LTD

Contact:86-536-2222176

Address:weifang,shandong
Tianjin Dongchang Fine Chemical Industry Co., Ltd.

Contact:+86-22-29894595

Address:Economic Developing Zone, Ji County, Tianjin, China
Nantong Chem-land Co., Ltd.

Contact:86 513 85512619

Address:Rm.1306, Building A, Wenfeng Mansion,168 Gongnong Road, Nantong Jiangsu China

Relevant to this article

One-pot synthesis of cyclic carbonates from aldehydes, sulfur ylide, and CO₂

Doi:10.1055/s-0033-1340072
(2014)
Hydroxyl group-assisted palladium-catalyzed lactonization of homoallylic alcohols

Doi:10.1002/cctc.201300903
(2014)
Preparation and reactions of heteroarylmethylzinc reagents

Doi:10.1021/ol500790p
(2014)
An efficient and green synthesis of phthalide-fused pyrazole and pyrimidine derivatives

Doi:10.1016/j.tetlet.2014.02.101
(2014)
Microwave-assisted alkylations of activated methylene groups

Doi:10.1080/00397919508010781
(1995)
Synthesis of 2'-deoxy-pyranosyl nucleosides from glycals through consecutive addition of phenylselenyl chloride and glycosylation. A study of factors controlling the stereoselectivity

Doi:10.1016/S0040-4020(01)89572-7
(1994)

Article Doi