Synthesis of cytosine>-2'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide). Analogues of the Highly specific Anti-HIV-1 Agent TSAO-T

DOI: 10.1016/S0040-4020(01)85711-2

Source and publish data:

Tetrahedron p. 11013 - 11022 (1994)

Update date:2022-08-03

Topics:

Authors:

Velazquez, Solones

Jimeno, Maria-Luisa

Camarasa, Maria-Jose

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Article abstract of DOI:10.1016/S0040-4020(01)85711-2

Reaction of O-mesylcyanohydrins of furanos-2'-ulosyl cytosine with bases afforded β-D-arabino- and ribo-2'-spiro substituted nucleosides.Two of them exist, in solution, as mixtures of rotationally restricted "syn-anti" isomers.

Full text of DOI:10.1016/S0040-4020(01)85711-2

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Product name:1-<2'-C-cyano-2'-O-mesyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-arabinofuranosyl>-4-N-(monomethoxytrityl)cytosine

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