A highly diastereoselective [3+3] annulation reaction of aza-oxyallyl cations and nitrones

Article abstract of DOI:10.1016/j.tetlet.2018.03.085

An efficient synthesis of 1,2,4-oxadiazinan-5-ones via [3+3] cycloaddition of in situ generated aza-oxyallyl cations with nitrones has been developed. The protocol features easy operation, excellent yields, excellent diastereo-control, broad substrate sco