A chemoenzymatic approach to chiral phenylisoserinates using 4-isopropyl-2-oxazolin-5-one as masked umpoled synthon for hydroxycarbonyl anion

DOI: 10.1016/0040-4039(94)88490-0

Source and publish data:

Tetrahedron Letters p. 9289 - 9292 (1994)

Update date:2022-07-30

Topics:

Authors:

Barco, Achille

Benetti, Simonetta

De Risi, Carmela

Pollini, Gian P.

Romagnoli, Romeo

Zanirato, Vinicio

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Article abstract of DOI:10.1016/0040-4039(94)88490-0

The aldol adduct between the anion of 4-isopropyl-2-oxazolin-5-one with racemic N-(tertbutoxycarbonyl)-phenylglycinal underwent concomitant isomerization and ring cleavage under mild basic conditions producing the racemic dipeptide N-Boc-phenylisoserine-v

Full text of DOI:10.1016/0040-4039(94)88490-0

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