A chemoenzymatic approach to chiral phenylisoserinates using 4-isopropyl-2-oxazolin-5-one as masked umpoled synthon for hydroxycarbonyl anion

Article abstract of DOI:10.1016/0040-4039(94)88490-0

The aldol adduct between the anion of 4-isopropyl-2-oxazolin-5-one with racemic N-(tertbutoxycarbonyl)-phenylglycinal underwent concomitant isomerization and ring cleavage under mild basic conditions producing the racemic dipeptide N-Boc-phenylisoserine-v