Organic Process Research and Development p. 744 - 750 (2014)
Update date:2022-09-26
Topics:
Zheng, Yong-Yong
Shen, Cheng-Wu
Zhu, Mei-Yu
Zhou, Yi-Meng
Li, Jian-Qi
Synthetic impurities that are present in dabigatran etexilate mesylate were studied, and possible pathways by which these impurities are formed during the manufacturing process were examined. The impurities were monitored by high-performance liquid chromatography, and their structures were determined by mass spectrometry and 1H and 13C NMR. Potential causes for the formation of these impurities are discussed, and strategies to minimize their formation are also described.
View MoreSHANXI JINJIN CHEMICAL INDUSTRIAL CO.,LTD
website:http://www.jinjingroup.com
Contact:4009982989
Address:Economic And Technological Development Zone,Hejin?City,Shanxi Province?,China
Quzhou Aokai Chemical Co., Ltd.
Contact:86-570-3032832
Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China
TIANJIN BAOLIRUITE CHEMICALS CO.,LTD
Contact:+86-022-58652605
Address:NO.60,xiqing high-end metal products industrial zone, Tianjin, China.
Guangxi Shanyun Biochemical Science and Technology Co., Ltd
Contact:+86-0772--6828887
Address:#2 Industrial Park of Luzhai County, Liuzhou, Guangxi, China
Luoyang Aoda chemical Co.,Ltd.
Contact:+86-379-67518785 67516588
Address:MiaoWan industry district,YanShi City,Henan,China
Doi:10.1021/jm00006a010
(1995)Doi:10.1021/jm5001908
(2014)Doi:10.1016/S0040-4039(99)01100-4
(1999)Doi:10.1021/jo00106a031
(1995)Doi:10.1016/j.tetlet.2014.05.040
(2014)Doi:10.1039/c4cp05829a
(2015)