2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii

Article abstract of DOI:10.1021/jm00005a002

2,4-Diaminoquinazoline antifolates with a lipophilic side chain at the 5- position, and in one case with a classical (p-aminobenzoyl)-L-glutamate side chain, were synthesized as potentially selective inhibitors of a site- directed mutant of human dihydrof