Synthesis of CF3-Substituted Quinolines from β-Chloro-β-trifluoromethyl-vinylaldehydes. I.

Article abstract of DOI:10.1002/prac.19953370107

3-(Trifluoromethyl)-acroleines 2 have been synthesized through VILSMEIER's reaction from α-Trifluoromethylketones 1.The reaction of 2 with anilines and naphthylamines gives in good yields 2-trifluoromethylquinolines 4 and benzoquinolines 5.