J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs

Article abstract of DOI:10.1016/0960-894X(96)00033-9

J-104,123, a potent inhibitor of squalene synthase having monocarboxylic acid structure, was discovered by chemical modification of J-104,118. An oral dose of J-104,123 lowered serum cholesterol levels in dogs. J-104,123 was synthesized stereoselectively from methyl (R)-3-hydroxybutyrate.