Molecules p. 102 - 121 (2014)
Update date:2022-08-04
Topics:
Wang, Wen-Long
Yang, Dong-Lin
Gao, Li-Xin
Tang, Chun-Lan
Ma, Wei-Ping
Ye, Hui-Hua
Zhang, Si-Qi
Zhao, Ya-Nan
Xu, Hao-Jie
Hu, Zhao
Chen, Xia
Fan, Wen-Hua
Chen, Hai-Jun
Li, Jing-Ya
Nan, Fa-Jun
Li, Jia
Feng, Bainian
A series of 1H-2,3-dihydroperimidine derivatives was designed, synthesized, and evaluated as a new class of inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC50 values in the micromolar range. Compounds 46 and 49 showed submicromolar inhibitory activity against PTP1B, and good selectivity (3.48-fold and 2.10-fold respectively) over T-cell protein tyrosine phosphatases (TCPTP). These results have provided novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs.
View MoreNingbo Distant Chemicals Co.,Ltd
Contact:86-574-27862490,27862438
Address:5F-3,#54 DaShaNi street,Ningbo,CHINA
Anhui Biochem United Pharmaceutical Co., Ltd.
Contact:0086 551 5167062 / 5228268
Address:No. 30 Hongfeng Road, Hi-Tech Development Zone, Hefei (230088), China
Hunan Shineway Enterprise Co., Ltd.
Contact:+86-731-86303875
Address:118, Huanghua International Airport Road, Huanghua Town, Changsha, Hunan 410137, China
Nanjing Chemzam Pharmtech Co., Ltd.
Contact:+86-25-86462165,+86-13915979898
Address:C5-1,6 Maiyue Road,Maigaoqiao,Nanjing,Jiangsu,China
Contact:+86+21-58956006 15800617331
Address:402 Room, 150# Cailun Road, Zhangjiang high tech park, Shanghai
Doi:10.1016/j.bmcl.2014.06.063
(2014)Doi:10.1016/S0022-328X(96)06480-7
(1996)Doi:10.1248/cpb.42.2196
(1994)Doi:10.1021/acsmedchemlett.6b00242
(2016)Doi:10.1055/s-0033-1341045
(2014)Doi:10.1246/bcsj.68.183
(1995)