Ligand exchange reaction of sulfoxides in organic synthesis: A new method for one-carbon homologation of esters to carboxylic acids and esters via α- chloro α-sulfinyl ketones

Article abstract of DOI:10.1016/0040-4039(94)88182-0

Reaction of the Carbanion of chloromethyl phenyl sulfoxide with esters gave α-chloro α-sulfinyl ketones, which were treated with KH followed by t- BuLi to afford one-carbon homologated acids and esters in good to excellent yields.