Evaluation of 2-bromocyclohexenone acetals as vehicles for the introduction of C-7 oxygen preliminary to the synthesis of taxane diterpenes

Article abstract of DOI:10.1021/jo00109a021

The coupling of an optically pure, camphor-derived, β,γ-unsaturated, bicyclic ketone with a suitable vinyl organometallic is recognized to result in 1,2-addition from the endo face. Anionic oxy-Cope rearrangement of these carbinols proceeds via an 'endo-c