Synthetic Studies on Oligomycins. Enantiospecific Synthesis of the Oligomycin B Spiroketal Portion and Establishment of the Absolute Stereochemistry of Oligomycin B

Article abstract of DOI:10.1016/S0040-4039(00)61353-9

The enantiospecific synthesis of the oligomycin B degradation product 2, corresponding to the C19-C34 spiroketal portion, has been achieved by sequential coupling of the C19-C21, C22-C27, and C28-C34 subunits, establishing the absolute stereochemistry of oligomycin B.