The synthesis of novel melphalan derivatives as potential antineoplastic agents

DOI: 10.1016/S0223-5234(97)89087-3

Source and publish data:

European Journal of Medicinal Chemistry p. 343 - 349 (1997)

Update date:2022-08-03

Topics:

Authors:

Morris Morris

Atassi Atassi

Guilbaud

Cordi Cordi

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Article abstract of DOI:10.1016/S0223-5234(97)89087-3

Five derivatives of melphalan (S)-4-[bis(2-chloroethyl)amino]phenylalanine), an alkylating agent presently employed as an antieoplastic in humans, were designed and synthesised as potential prodrugs. Their antitumour activity was tested against P388 leuka

Full text of DOI:10.1016/S0223-5234(97)89087-3

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