A-Ring Ortho-Disubstituted Aporphine Derivatives as Potential Agonists or Antagonists at Serotonergic 5-HT1A Receptors

Article abstract of DOI:10.1021/jm00011a002

(R)- And (S)-11-hydroxy-10-methylaporphine 1 and 2 are, respectively, a potent, highly specific serotonergic (5-HT_1A) agonist and antagonist.In an ongoing structure-activity study, racemates of the positional isomers 8-hydroxy-9-methyl- and 8-m