Synthese der Pestwurzinhaltsstoffe (+)-Petasin und (+)-Isopetasin

Article abstract of DOI:10.1016/0040-4039(95)00475-R

The first total synthesis of optically active petasine 1 and isopetasine 2 succeeded by applying an annelation reaction, based on the reaction of cyclic δ-ketocarboxylic acids with N-phenyliminoketenylidenetriphenylphosphorane. 1 and 2 are biologically ac