A simple approach to the synthesis of a chiral substituted chroman ring of calophyllum coumarins

Article abstract of DOI:10.1055/s-1995-3987

A stereoselective synthesis of the chiral 2,3-dimethylchroman-4-ol ring of the calophyllum coumarins is described. The chiral centers at C-3 and C-4 (chroman numbering) were introduced using (Z)-crotyldiisopinocampheylborane, and the chiral center at C-2