Synthesis and Biological Evaluation of Paclitaxel Analogs Modified in Ring C

DOI: 10.1016/0040-4039(95)00431-B

Source and publish data:

Tetrahedron Letters p. 2901 - 2904 (1995)

Update date:2022-07-30

Topics: Synthesis Optimization Structure-Activity Relationship (SAR) Analysis Preclinical and Clinical Development Design and Rationalization Lead Identification

Authors:

Liang, Xian

Kingston, David G. I.

Lin, Chii M.

Hamel, Ernest

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Article abstract of DOI:10.1016/0040-4039(95)00431-B

Both 7-deoxy-7α-azidopaclitaxel (6) and 7-deoxy-Δ^6,7-paclitaxel (4) can be prepared from paclitaxel-7-O-triflate (2b).Oxidation of 7-deoxy-Δ^6,7-paclitaxel with dioxirane yields the epoxide 7, while oxidation with osmium tetroxide yie

Full text of DOI:10.1016/0040-4039(95)00431-B

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