
Tetrahedron Letters p. 2901 - 2904 (1995)
Update date:2022-07-30
Topics: Synthesis Optimization Structure-Activity Relationship (SAR) Analysis Preclinical and Clinical Development Design and Rationalization Lead Identification
Liang, Xian
Kingston, David G. I.
Lin, Chii M.
Hamel, Ernest
Both 7-deoxy-7α-azidopaclitaxel (6) and 7-deoxy-Δ6,7-paclitaxel (4) can be prepared from paclitaxel-7-O-triflate (2b).Oxidation of 7-deoxy-Δ6,7-paclitaxel with dioxirane yields the epoxide 7, while oxidation with osmium tetroxide yie
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