Variation of the Alkyl Side Chain in Δ8-THC

Article abstract of DOI:10.1016/0024-3205(95)00184-8

The synthesis of (2'RS)-2'-methyl-, (3'RS)-, (3'S)-3'-methyl-, and 4'-methyl-Δ⁸-THC has been carried out, and the pharmacology of all four compounds has been investigated. All four compounds showed typical cannabinoid activity both in vitro and in vivo. The 2'-methyl compound is somewhat more active than Δ⁸-THC, while the 4'-methyl isomer is less active. The 3'-methyl-Δ⁸-THC has approximately the same activity as the parent cannabinoid.