Life Sciences p. 2021 - 2024 (1995)
Update date:2022-07-29
Topics:
Huffman, John W.
Lainton, Julia A. H.
Dai, Dong
Jordan, Robert D.
Duncan, Sammy G.
The synthesis of (2'RS)-2'-methyl-, (3'RS)-, (3'S)-3'-methyl-, and 4'-methyl-Δ8-THC has been carried out, and the pharmacology of all four compounds has been investigated. All four compounds showed typical cannabinoid activity both in vitro and in vivo. The 2'-methyl compound is somewhat more active than Δ8-THC, while the 4'-methyl isomer is less active. The 3'-methyl-Δ8-THC has approximately the same activity as the parent cannabinoid.
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