Preparation of 1,3-disubstituted isoquinoline derivatives from N-Boc-3-substituted-1,2-dihydroisoquinolones

Article abstract of DOI:10.1002/jhet.5570320115

3-Substituted N-Boc-1,2-dihydroisoquinolines 2 can be functionalized at the 1-position via lithiation and subsequent electrophilic trapping. The resulting products 3 can be deprotected and oxidized to afford the correspondihg 1,3-disubstituted isoquinolin