Efficient synthesis of carbapenems via the oxalimide cyclization. Manipulation of protecting groups at the oxalimide stage

DOI: 10.1016/0040-4039(95)00854-6

Source and publish data:

Tetrahedron Letters p. 4563 - 4566 (1995)

Update date:2022-08-04

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Authors:

King, Steven A.

Pipik, Brenda

Thompson, Andrew S.

DeCamp, Ann

Verhoeven, Thomas R.

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Article abstract of DOI:10.1016/0040-4039(95)00854-6

An efficient synthesis of the carbapenem nucleus from TBDMS protected acetoxyazetidinone via oxalimide cyclization technology is demonstrated. A key step is desilylation of the oxalimide intermediate. Access to a variety of protecting group schemes is demonstrated.

Full text of DOI:10.1016/0040-4039(95)00854-6

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