Efficient synthesis of carbapenems via the oxalimide cyclization. Manipulation of protecting groups at the oxalimide stage

DOI: 10.1016/0040-4039(95)00854-6

Source and publish data:

Tetrahedron Letters p. 4563 - 4566 (1995)

Update date:2022-08-04

Topics:

Authors:

King, Steven A.

Pipik, Brenda

Thompson, Andrew S.

DeCamp, Ann

Verhoeven, Thomas R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)00854-6

An efficient synthesis of the carbapenem nucleus from TBDMS protected acetoxyazetidinone via oxalimide cyclization technology is demonstrated. A key step is desilylation of the oxalimide intermediate. Access to a variety of protecting group schemes is demonstrated.

Full text of DOI:10.1016/0040-4039(95)00854-6

Products guided by the article

Product name:[(2R,3S)-2-[2-(5-Cyano-4'-hydroxymethyl-biphenyl-3-yl)-2-oxo-ethyl]-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-1-yl]-oxo-acetic acid allyl ester

Cas No:165548-34-5

R&D Labs maybe for 165548-34-5

Shandong Zhongcheng Barium Salt Co., Ltd

Contact:+86-15725732638

Address:No.29 baoxi road, hi-tech zone, zibo, shandong
Shanghai Mintchem Development ., Ltd

Contact:0086 21 5190 8570

Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
Shandong Hongxiang Zinc Co., Ltd

Contact:086-0311-66187879

Address:DaWang developing zone
Improve Medical Technology(Nanxiong) Co., Ltd

Contact:86-751-3836997

Address:No.33, Pingan First Road, Fine Chemical Industry Base, Nanxiong City, Shaoguan, Guangdong, China
henan victory industry co.ltd

Contact:86-371-63655023

Address:No.85,jinshui road,zhengzhou,China

Relevant to this article

Aryl-palladium-NHC complex: Efficient phosphine-free catalyst precursors for the carbonylation of aryl iodides with amines or alkynes

Doi:10.1039/c4ob01878h
(2014)
Modification of Receptor Selectivity and Functional Activity in Cholecystokinin Peptoid Ligands

Doi:10.1021/jm00017a022
(1995)
Metallorganische Verbindungen der Lanthanoide XCVIII. Synthese und Strukturaufklaerung von Dichloro(η⁵-2,5-di-tert.-butylpyrrolyl)bis(tetrahydrofuran)ytterbium(III)

Doi:10.1016/0022-328X(95)05495-B
(1995)
Doi:10.1016/S0031-9422(00)86667-4
(1968)
Synthesis and multinuclear NMR studies of 3-aminopropyl(aryl)chalcogenides, NH2CH2CH2CH2EAr (E=Se, Te), and their complexes with Pt(II) and Pd(II)

Doi:10.1016/0022-328X(95)05403-C
(1995)
Chemistry of ^0,+ (HL = 8-hydroxyquinoline): Synthesis, Structure, Metal Redox Behaviour and Isomer Selectivity

Doi:10.1039/DT9950001417
(1995)

Article Doi