Journal of Heterocyclic Chemistry p. 675 - 681 (1995)
Update date:2022-07-30
Topics: Characterization Optimization Biological applications Validation Binding Studies Selection of Building Blocks
Papadopoulou
Goswami
Hamilton
Open chain podands 2a-c and macrocycles 2d-e have been synthesized as potential candidates for 4-aminopterin recognition and binding, featuring H-bonding characteristics and 'stacking interaction' 2e. Preliminary binding studies between 6, 7, and 8 (simpler analogs of the above 2a-e) as 'hosts' and appropriate 'guests', showed that carbamates 2a and 2e are the most promising receptors for 4-aminopterin binding.
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