Novel Antagonists of Platelet-Activating Factor. 1. Synthesis and Structure-Activity Relationships of Benzodiazepine and Benzazepine Derivatives of 2-Methyl-1-phenylimidazopyridine

DOI: 10.1021/jm00018a011

Source and publish data:

Journal of Medicinal Chemistry p. 3514 - 3523 (1995)

Update date:2022-07-29

Topics:

Authors:

Fray, M. Jonathan

Cooper, Kelvin

Parry, M. John

Richardson, Kenneth

Steele, John

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00018a011

Following the discovery of moderately potent antagonist activity against platelet-activating factor (PAF) in 2-methyl-1-phenylimidazo<4,5-c>pyridine (2) (IC50=840 nM), 19 derivatives (3-21) were prepared which incorporated various lipophilic groups attach

Full text of DOI:10.1021/jm00018a011

Products guided by the article

Product name:(4-Iodo-phenyl)-(3-nitro-pyridin-4-yl)-amine

Cas No:167694-20-4

R&D Labs maybe for 167694-20-4

Suzhou Credit International Trading Co., Ltd

Contact:+86-512-65398039

Address:Qingdeng, Hightech. District, Suzhou
Shanghai He Yang International Trading Co., Ltd.

Contact:+86-21-52043598

Address:Room 816, Blag.5, No.58 Huachi Road
Hangzhou Ledun Technology Co.,Ltd.

Contact:86-571-18767088918

Address:No.6 street,XiaSha,Hangzhou,China.
Kaiping Genuine Biochemical Pharmaceutical Co.,Ltd.

Contact:+86-750-2881198

Address:No.1, Xinke Road, Shatang Town, Kaiping, Guangdong Province, P.R.China
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.

Contact:0086-0576-88551200,88886292 ,88880039

Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China

Relevant to this article

Synthetic studies on trifluoroacetylindoles

Doi:10.3987/COM-99-8480
(1999)
Isomeric trimethylene and ethylene pendant-armed cross-bridged tetraazamacrocycles and in vitro/in vivo comparisions of their copper(II) complexes

Doi:10.1021/ic200014w
(2011)
Selective electrolytic removal of bis(alkoxycarbonyl)methano addends from C₆₀ bis-adducts and electrochemical stability of C₇₀ derivatives

Doi:10.1002/1521-3765(20000616)6:12<2184::AID-CHEM2184>3.0.CO;2-6
(2000)
3'-Deoxy-3'-(vinylsulphonyl)thymidine - A New Reactive Analogue of AZT: Its Synthesis and Reactivities Towards Various Nucleophiles

Doi:10.1016/0040-4020(95)00403-U
(1995)
Synthesis and fugicidal activities of 2-silatranyl propylamino-4-substitued phenyl(hydrogen)-5,5-dimethyl-1,3,2-dioxaphosphinanes-2-oxides (sulfides)

Doi:10.1080/104265090968343
(2005)
Highly Selective Aldol Reaction of Dibenzoylmethanes with Formaldehyde Catalyzed by Cobalt Schiff Base Complex under Neutral Conditions

Doi:10.1016/00404-0399(50)1074R-
(1995)

Article Doi