Novel Antagonists of Platelet-Activating Factor. 1. Synthesis and Structure-Activity Relationships of Benzodiazepine and Benzazepine Derivatives of 2-Methyl-1-phenylimidazopyridine

DOI: 10.1021/jm00018a011

Source and publish data:

Journal of Medicinal Chemistry p. 3514 - 3523 (1995)

Update date:2022-07-29

Topics:

Authors:

Fray, M. Jonathan

Cooper, Kelvin

Parry, M. John

Richardson, Kenneth

Steele, John

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Article abstract of DOI:10.1021/jm00018a011

Following the discovery of moderately potent antagonist activity against platelet-activating factor (PAF) in 2-methyl-1-phenylimidazo<4,5-c>pyridine (2) (IC50=840 nM), 19 derivatives (3-21) were prepared which incorporated various lipophilic groups attach

Full text of DOI:10.1021/jm00018a011

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