Journal of Organic Chemistry p. 6937 - 6940 (1995)
Update date:2022-08-03
Topics:
Wolf, Eckardt
Spenser, Ian D.
An eight-step synthesis of <2,3-(13)C2>-4-hydroxy-L-threonine <<2,3-(13)C2>-(2S,3S)-2-amino-3,4-dihydroxybutanoic acid> is described, starting from <1,2-(13)C2>acetylene, in an overall yield of 13percent.Since a key intermediate of the synthetic sequence, 4-(benzyloxy)-(Z)-but-2-en-1-ol, is available commercially, the method furnishes a convenient four-step synthesis of nonenriched 4-hydroxy-L-threonine, in an overall yield of 27percent.
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Doi:10.1021/ja01191a051
(1948)Doi:10.1139/v63-323
(1963)Doi:10.1021/jo01148a001
(1950)Doi:10.1021/jo015986p
(2002)Doi:10.1021/ic00130a007
()Doi:10.1021/jo01161a006
(1948)
