-4-Hydroxy-L-threonine

Article abstract of DOI:10.1021/jo00126a052

An eight-step synthesis of <2,3-(13)C2>-4-hydroxy-L-threonine <<2,3-(13)C2>-(2S,3S)-2-amino-3,4-dihydroxybutanoic acid> is described, starting from <1,2-(13)C2>acetylene, in an overall yield of 13percent.Since a key intermediate of the synthetic sequence, 4-(benzyloxy)-(Z)-but-2-en-1-ol, is available commercially, the method furnishes a convenient four-step synthesis of nonenriched 4-hydroxy-L-threonine, in an overall yield of 27percent.