9-Substituted acridine derivatives with long half-life and potent antitumor activity: Synthesis and structure-activity relationships

DOI: 10.1021/jm00017a006

Source and publish data:

Journal of Medicinal Chemistry p. 3226 - 3235 (1995)

Update date:2022-08-05

Topics:

Authors:

Chou Chou

Joong Young Kim

Huang Huang

Ciszewska

Ren - Ren -

Otter Otter

Sirotnak

Watanabe

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Article abstract of DOI:10.1021/jm00017a006

A series of DNA-intercalating 9-anilinoacridines, namely 9- phenoxyacridines, 9-(phenylthio)-acridines, and 9-(3',5'-disubstituted anilino)acridines, were synthesized as potential antitumor agents with inhibitory effects on DNA topoisomerase II. Unlike am

Full text of DOI:10.1021/jm00017a006

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