9-Substituted acridine derivatives with long half-life and potent antitumor activity: Synthesis and structure-activity relationships

DOI: 10.1021/jm00017a006

Source and publish data:

Journal of Medicinal Chemistry p. 3226 - 3235 (1995)

Update date:2022-08-05

Topics:

Authors:

Chou Chou

Joong Young Kim

Huang Huang

Ciszewska

Ren - Ren -

Otter Otter

Sirotnak

Watanabe

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00017a006

A series of DNA-intercalating 9-anilinoacridines, namely 9- phenoxyacridines, 9-(phenylthio)-acridines, and 9-(3',5'-disubstituted anilino)acridines, were synthesized as potential antitumor agents with inhibitory effects on DNA topoisomerase II. Unlike am

Full text of DOI:10.1021/jm00017a006

Products guided by the article

Product name:4-<(3-methoxy-9-acridinyl)thio>benzyl alcohol

Cas No:168556-42-1

R&D Labs maybe for 168556-42-1

Chongqing Werlchem Fine Chemical Co. Ltd

Contact:+86-23-67521957

Address:NO.15,Fortune Road,Yubei District,401121,Chongqing,China
Shanghai Hohance Chemical Co., ltd

Contact:13914753421

Address:Fl.5；Bld. 70, Lane 1500; Xinfei Road
Shanghai Taibao Pharmaceutical Technology Co., Ltd(expird)

Contact:021-52217366

Address:shanghai
Hebei Think-Do Environment Co., Ltd

website:http://www.thinkdo-environment.com

Contact:0311-86510809-

Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
Jiangxi Dongbang Pharmaceutical Co., Ltd.

Contact:+86-795-4433603, 4433388

Address:Fengxin Industrial Park, Fengxin County, Jiangxi Province, P.R.C

Relevant to this article

Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication

Doi:10.1128/AAC.39.10.2253
(1995)
Sialyl Lewis X-polysaccharide conjugates: Targeting inflammatory lesions

Doi:10.1016/S0960-894X(98)00488-0
(1998)
N-Substitution of 2-Methyl-4(5)-nitro-1H-imidazole: A New, High-Yielding Method for Preparation of 4-Nitro Isomers

Doi:10.1021/jo00298a070
(1990)
Practical synthesis of a C-glycosyl flavonoid via O→C glycoside rearrangement

Doi:10.1246/bcsj.68.1379
(1995)
Targeting type 2 diabetes with c-glucosyl dihydrochalcones as selective sodium glucose co-transporter 2 (sglt2) inhibitors: Synthesis and biological evaluation

Doi:10.1021/acs.jmedchem.6b01134
(2017)
Polymerization of new aniline derivatives: synthesis, characterization and application as sensors

Doi:10.1039/d1ra02474d
(2021)

Article Doi