Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group

DOI: 10.1021/jm00014a010

Source and publish data:

Journal of Medicinal Chemistry p. 2570 - 2581 (1995)

Update date:2022-09-26

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Authors:

Gowravaram

Tomczuk Tomczuk

Johnson Johnson

Delecki Delecki

Cook Cook

Ghose Ghose

Mathiowetz

Spurlino

Rubin Rubin

Smith Smith

Pulvino Pulvino

Wahl Wahl

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Article abstract of DOI:10.1021/jm00014a010

In this study, structure-based drug design of matrix metalloproteinase inhibitors [human fibroblast collagenase (HFC), human fibroblast stromelysin (HFS), and human neutrophil collagenase (HNC)] was utilized in the development of potent hydroxamates which

Full text of DOI:10.1021/jm00014a010

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