Synthesis of Xaa-Gly-Xaa' Keto-Methylene Tri-peptide Isosteres Incorporating Phenylalanine, Tyrosine and Valine Units.

Article abstract of DOI:10.1016/0040-4039(95)00564-S

The utility of amino-acid derived β-ketosulfones in the synthesis of keto-methylene tri-peptide isosteres Xaa-Gly-Xaa', incorporating phenylalanine, tyrosine and valine units is reported.Both L,L andL,D forms of the tripeptide systems have been prepared using this methodology.