Tripeptide growth hormone secretagogues

DOI: 10.1016/S0960-894X(98)00103-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 759 - 764 (1998)

Update date:2022-08-03

Topics:

Authors:

Yang, Lihu

Morriello, Greg

Pan, Yanping

Nargund, Ravi P.

Barakat, Khaled

Prendergast, Kristine

Cheng, Kang

Chan, Wanda W.-S.

Smith, Roy G.

Patchett, Arthur A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00103-6

A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) sccretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa- hepta-GH releasing peptides can be mimicked at the tripeptide level.

Full text of DOI:10.1016/S0960-894X(98)00103-6

Products guided by the article

Product name:(R)-2-[(R)-2-(2-tert-Butoxycarbonylamino-2-methyl-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid ethyl ester

Cas No:170845-84-8

R&D Labs maybe for 170845-84-8

Nantong Kaixin Pharma Chemical Co.,Ltd.

Contact:86-513-85250786

Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
Hefei TNJ chemical industry co.,ltd

website:https://www.tnjchem.com

Contact:+86-551-65418695

Address:B911 Xincheng Business Center, Qianshan Road, Hefei Anhui China
SHANDONG ZHANHUA YONGHAO PHARMACEUTICAL TECH.CO.,LTD

Contact:+86-576-88685096

Address:GENGJU VILLAGE NORTH ONE KILOMETER,ZHANHUA DISTRICT,BINZHOU CITY,SHANDONG PROVINCE,CHINA.
Suqian Ruixing Chemical Co., Ltd.

Contact:+86-527-80805666（总机）;84836008(销售)

Address:3 Jingsilu, Zone north, Hubin Xincheng Development Park, Suqian, China
Shao Xing Empire Import&Export CO.,ltd

Contact:86-575-82127757

Address:11#, Weiwu Road, Shangyu Industrial Park, Hangzhou Bay, Hangzhou, Zhejiang Province, China

Relevant to this article

Synthesis of benzyl O-(3-O-methyl-β-D-galactopyranosyl)-(1 → 3)-2-acetamido-2-deoxy-α-D-galactopyranoside and benzyl O-(β-D-galactopyranosyl)-(1 → 3)-2-acetamido-2-deoxy-6-O-methyl-α-D-galactopyranoside as specific acceptors for sialyltransferases

Doi:10.1016/0008-6215(95)00072-2
(1995)
Doi:10.1016/S0022-328X(00)81731-3
(1967)
Doi:10.1007/BF02724385
(1959)
Structure-activity relationships of 1-(2-deoxy-2-fluoro-β-L-arabino- furanosyl)pyrimidine nucleosides as anti-hepatitis B virus agents

Doi:10.1021/jm960098l
(1996)
Isopropyllithium diamine adducts: From a non symmetric aggregate to monomeric i-PrLi·(1R,2R)-N,N,N′,N′-tetraethylcyclohexane-1,2- diamine

Doi:10.1039/b804855j
(2008)
Baker's yeast reduction of arylidenecycloalkanones

Doi:10.1016/0040-4020(95)00578-V
(1995)

Article Doi