Tripeptide growth hormone secretagogues

DOI: 10.1016/S0960-894X(98)00103-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 759 - 764 (1998)

Update date:2022-08-03

Topics:

Authors:

Yang, Lihu

Morriello, Greg

Pan, Yanping

Nargund, Ravi P.

Barakat, Khaled

Prendergast, Kristine

Cheng, Kang

Chan, Wanda W.-S.

Smith, Roy G.

Patchett, Arthur A.

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Article abstract of DOI:10.1016/S0960-894X(98)00103-6

A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) sccretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa- hepta-GH releasing peptides can be mimicked at the tripeptide level.

Full text of DOI:10.1016/S0960-894X(98)00103-6

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