Bioorganic and Medicinal Chemistry Letters p. 759 - 764 (1998)
Update date:2022-08-03
Topics:
Yang, Lihu
Morriello, Greg
Pan, Yanping
Nargund, Ravi P.
Barakat, Khaled
Prendergast, Kristine
Cheng, Kang
Chan, Wanda W.-S.
Smith, Roy G.
Patchett, Arthur A.
A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) sccretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa- hepta-GH releasing peptides can be mimicked at the tripeptide level.
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