The synthesis of haptens and properties of catalytic antibodies designed to catalyse carbanionic cyclisation reactions

Article abstract of DOI:10.1016/0040-4020(95)00500-8

The design of haptens to generate antibodies with the potential to catalyse carbanionic cyclisation reactions is introduced in the context of Dieckmann cyclisations and related reactions. Syntheses of five-membered ring haptens containing a sulphone, to represent the transition state(s) associated with the tetrahedral intermediate, and an amino group, to promote the formation of a general base, are described. Results with partially purified antibodies are reported showing that the target reaction can be catalysed by antibodies.