Synthesis of various model compounds for the conjugated heterocyclic ring system of antibiotic roseophilin

Article abstract of DOI:10.1016/0040-4039(95)01822-Y

The title synthesis was accomplished starting with 3-chloro-2-formylpyrrole. The synthetic scheme featured one-pot preparation of the 4-methoxy-2-(pyrrol-2-yl)furan from the 2-acetoacetylpyrrole and coupling reactions of the C₅-position of the