High enantiocontrol of Michael additions by use of 2,2-dimethyloxazolidine chiral auxiliaries. Exclusively ul,lk-1,4-inductive Michael additions of the lithium (Z)-enolate of (S)-4-benzyl-2,2,5,5-tetramethyl-3-propanoyl-oxazolidine to α,β-unsaturated este

Article abstract of DOI:10.1016/0040-4020(95)00623-G

The lithium (Z)-enolate generated from the propanamide of (S)-4-benzyl-2,2,5,5-tetramethyloxazolidine undergoes highly lk-1,4/anti-selective Michael additions to α,β-unsaturated ester and amide acceptors. However, only poor selectivities result when eithe