A facile synthesis of 5-substituted 2-furylacetates via 6-hydroxy-3-oxo-4-hexenoates

DOI: 10.1016/0040-4039(95)01612-L

Source and publish data:

Tetrahedron Letters p. 7685 - 7688 (1995)

Update date:2022-08-03

Topics:

Authors:

Kawano, Tomikazu

Ogawa, Toru

Islam, Saiful Md.

Ueda, Ikuo

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Article abstract of DOI:10.1016/0040-4039(95)01612-L

6-Substituted 3-ethoxy-6-hydroxy-2,4-hexadenoates (4) which were prepared by reaction of ethyl (4E)-3-ethoxy-5-formyl-2,4-pentadienoate (3a) with nucleophiles or sodium borohydride reduction of 6-substituted 3-ethoxy-6-oxo-2,4-hexadenoates (3b-e) have been converted in very good yields into 5-substituted 2-furylacetates (5) by treating with 47% HBr in THF.

Full text of DOI:10.1016/0040-4039(95)01612-L

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