Synthesis of 5-methyl-2'-O-deoxycytidine analogs to determine monoclonal antibody specificity in the recognition of the 6-(p-bromobenzoylamino) caproyl radical

Article abstract of DOI:10.1080/07328319708001362

Eight new p-bromobenzoyl derivatives of 5-methyl-2'-O-deoxycytidine analogs, substituted at the 4-position, were synthesized. The best conditions for obtaining 5-methyl-4-N-aminoalkyl-2'-O-deoxycytidine from 3',5'-di-O- acetyl-4-(1,2,4-triazol-1-yl)-2'-O-deoxythymidine were studied. The nucleoside analogs were used to identify the fragment of the 6-(p- bromobenzoylamino)caproyl radical that binds to the monoclonal antibody obtained against it and to define an affinity scale of monoclonal antibody against them.

Full text of DOI:10.1080/07328319708001362

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Synthesis of 5-Methyl-2′-O-
Deoxycytidine Analogs to Determine
Monoclonal Antibody Specificity
in the Recognition of the 6-(p-
Bromobenzoylamino) Caproyl Radical
Chryslaine Rodriguez-Tanty a , David Higginson-Clarke b , Milenen
Hernández a , Rafaela Pérez a , Hermán Vélez-Castro a , Ana Ma.
Riverón b & Arturo Macías a
a Organic Chemistry Department , National Center for Scientific
Research , P.O. Box 6880, Havana, Cuba
b Molecular Biology Department , National Center for Scientific
Research , P.O. Box 6880, Havana, Cuba
Published online: 21 Aug 2006.
To cite this article: Chryslaine Rodriguez-Tanty , David Higginson-Clarke , Milenen Hernández ,
Rafaela Pérez , Hermán Vélez-Castro , Ana Ma. Riverón & Arturo Macías (1997) Synthesis of
5-Methyl-2′-O-Deoxycytidine Analogs to Determine Monoclonal Antibody Specificity in the
Recognition of the 6-(p-Bromobenzoylamino) Caproyl Radical, Nucleosides and Nucleotides, 16:4,
455-467, DOI: 10.1080/07328319708001362
To link to this article: http://dx.doi.org/10.1080/07328319708001362
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