
Tetrahedron p. 869 - 876 (1996)
Update date:2022-08-02
Topics:
Aoyagi, Yutaka
Manabe, Tomofumi
Ohta, Akihiro
Kurihara, Teruo
Pang, Gui-Lin
Yuhara, Takeo
First synthesis of pyrrolam A (1), a pyrrolizidine alkaloid from Streptomyces olivaceus, was accomplished. The SmI2-mediated intramolecular coupling reaction between a bromoalkyl and ynamide group gave solely a cyclized product, which was converted to pyrrolam A (1) efficiently.
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