Asymmetric synthesis of (+)- and (-)-eptazocine via an enzymatic reaction

Article abstract of DOI:10.3987/COM-95-7232

Starting from (R)-3-hydroxy-2-(p-methoxybenzyl)propyl acetate (R-(+)-4) prepared by enzymatic monoacetylation of 2-(p-methoxybenzyl)propane-1,3-diol (3) with lipase PS in the presence of vinyl acetate as an acetyl donor, lactones ( (+)- and (-)-6) were ob