Practical synthesis of α-(trifluoromethyl)phenylacetic acid

DOI: 10.1016/0022-1139(95)03338-6

Source and publish data:

Journal of Fluorine Chemistry p. 91 - 93 (1996)

Update date:2022-07-31

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Authors:

Nemeth, Gabor

Rakoczy, Eva

Simig, Gyula

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Article abstract of DOI:10.1016/0022-1139(95)03338-6

α-(Trifluoromethyl)phenylacetic acid (1) was synthesized in good overall yield starting from the cyanohydrin of α,α,α-trifluoroacetophenone, via hydrogenolysis of α-mesyloxy-α-(trifluoromethyl)phenylacetamide or ethyl α-mesyloxy-a-(trifluoromethyl)phenylacetate followed by acidic hydrolysis.

Full text of DOI:10.1016/0022-1139(95)03338-6

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Product name:α-Mesyloxy-α-(trifluoromethyl)phenylacetamide

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