Synthesis p. 48 - 52 (1996)
Update date:2022-07-29
Topics:
Enders, Dieter
Syrig, Ralf
Raabe, Gerhard
Fernández, Rosario
Gasch, Consolación
Lassaletta, José-María
Llera, José-Manuel
The enantioselective synthesis of α-substituted β-nitro nitriles 4 and β-nitroaldehydes 5 by Michael addition of formaldehyde SAMP-hydrazone 1 to nitroalkenes 2 in excellent overall yields and high enantiomeric excesses(ee = 90- > 99%) is described. Compound 1 constitutes a neutral chiral formyl anion and cyanide equivalent. The absolute configuration was determined by X-ray structure analysis of the crystalline SAMP-hydrazone 1,4-adduct 3e.
View MoreContact:+86-838-5655598
Address:Guanghan Nanfeng Industrial Zone
Jewim Pharmaceutical (Shandong) Co., Ltd
Contact:+8615621883869
Address:山东省泰安市高新技术产业开发区配天门大街西首
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
website:http://www.trustwe.com
Contact:+86-21-61551413
Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong
Haitong Chemical Industrial Co.,Ltd.
website:https://www.haitonglongwin.com/
Contact:+86-022-66221018
Address:18-701, No.99, The 4th Street, TEDA,
Hebei Fulong Import & Export Co., Ltd.
Contact:86-311-87795661
Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China
Doi:10.1021/ja01371a039
(1930)Doi:10.1016/0040-4039(96)00097-4
(1996)Doi:10.1016/0040-4039(96)00127-X
(1996)Doi:10.1016/S0040-4020(01)87186-6
(1993)Doi:10.1002/jps.2600640540
(1975)Doi:10.1016/S0040-4039(02)00499-9
(2002)
