Asymmetric aldol condensation of acetyl ferrocene with aromatic aldehydes via the formation of the β-cyclodextrin inclusion complexes

Article abstract of DOI:10.1016/0022-328X(95)05816-8

By the formation of β-cyclodextrin (β-CD) inclusion complex, the aldol condensation of the acetyl ferrocene (FcCOCH₃) with aromatic aldehyde was investigated. The study reveals that the definite asymmetry-inducing ability of β-CD gives optical yields of the products in the range 6.0-30.4%. Also, alkali metal halides at a lower reaction temperature, can also give different results on the stereoselectivity of the reaction system. When the experiment was carried out in the solid state condition, an enhanced optical yield was obtained.