Syntheses of (14β,15β,16β,17α)- and (14β,15α,16α,17α)-1,3,5(10)-Estratriene-2,3,14,15, 16,17-hexaols, Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor, and Their Activity

Article abstract of DOI:10.1271/bbb.60.405

Structures are proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and two possible candidates, (14β,15β,16β,17α)- and (14β,15α,16α,17α)-2,3,14,15,16,17-hexahydroxy-1,3,5(10)- estratrienes, were synthesized. Both compounds were potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.

Full text of DOI:10.1271/bbb.60.405

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Syntheses of (14β,15β,16β,17α)- and
(14β,15α,16α,17α)-1,3,5(10)-Estratriene-2,3,14,15,
16,17-hexaols, Possible Candidates for the
Inagami—Tamura Endogenous Digitalis-like Factor,
and Their Activity
Masayuki Sakakibaraa & Aki Ogawa Uchidaa
a Pharmaceutical Research Laboratories, Kirin Brewery Co., Ltd., 3 Miyahara-cho,
Takasaki, Gunma 370-12, Japan
Published online: 12 Jun 2014.
To cite this article: Masayuki Sakakibara & Aki Ogawa Uchida (1996) Syntheses of (14β,15β,16β,17α)- and
(14β,15α,16α,17α)-1,3,5(10)-Estratriene-2,3,14,15, 16,17-hexaols, Possible Candidates for the Inagami—Tamura
Endogenous Digitalis-like Factor, and Their Activity, Bioscience, Biotechnology, and Biochemistry, 60:3, 405-410, DOI:
10.1271/bbb.60.405
To link to this article: http://dx.doi.org/10.1271/bbb.60.405
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