Synthesis and evaluation of a series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(β-L-ribofuranosyl)-1H- benzimidazole (1263W94)

Article abstract of DOI:10.1080/15257770008032999

A series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2- isopropylamino-1-(β-L-ribofuranosyl)-1H-benzimidazole (1263W94) were synthesized and evaluated for activity against human cytomegalovirus (HCMV) and for cytotoxicity. The 2-substituents

Full text of DOI:10.1080/15257770008032999

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Synthesis and Evaluation of a Series of
2′-Deoxy Analogues of The Antiviral
Agent 5,6-Dichloro-2-Isopropylamino-1-
(β-L-Ribofuranosyl)-1H-Benzimidazole
(1263W94)
Joseph H. Chan a , Stanley D. Chamberlain a , Karen K. Biron a ,
Michelle G. Davis b , Robert J. Harvey b , Dean W. Selleseth b , Ronna
E. Dornsife b , Ernest H. Dark b , Lloyd W. Frick c , Leroy B. Townsend
d , John C. Drach e & George W. Koszalka f
a Divisions of Chemistry Glaxo Wellcome Inc. , 5 Moore Drive,
Research Triangle Park, NC, 27709
b Divisions of Pharmacology Glaxo Wellcome Inc. , 5 Moore Drive,
Research Triangle Park, NC, 27709
c Divisions of Bioanalysis and Drug Metabolism Glaxo Wellcome Inc. ,
5 Moore Drive, Research Triangle Park, NC, 27709
d Divisions of Therapeutic Research, Glaxo Wellcome Inc. , 5 Moore
Drive, Research Triangle Park, NC, 27709
e Department of Medicinal Chemistry, College of Pharmacy,
Department of Chemistry, College of Literature, Science and Arts ,
University of Michigan , Ann Arbor, MI, 48109
f Department of Biologic and Materials Sciences, School of
Dentistry , University of Michigan , Ann Arbor, MI, 48109
Published online: 24 Sep 2006.
To cite this article: Joseph H. Chan , Stanley D. Chamberlain , Karen K. Biron , Michelle G. Davis ,
Robert J. Harvey , Dean W. Selleseth , Ronna E. Dornsife , Ernest H. Dark , Lloyd W. Frick , Leroy
B. Townsend , John C. Drach & George W. Koszalka (2000) Synthesis and Evaluation of a Series of
2′-Deoxy Analogues of The Antiviral Agent 5,6-Dichloro-2-Isopropylamino-1-(β-L-Ribofuranosyl)-1H-
Benzimidazole (1263W94), Nucleosides, Nucleotides and Nucleic Acids, 19:1-2, 101-123, DOI:
10.1080/15257770008032999
To link to this article: http://dx.doi.org/10.1080/15257770008032999
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