
Bioorganic and Medicinal Chemistry Letters p. 1583 - 1588 (1997)
Update date:2022-08-04
Topics:
Sher, Philip M.
Mathur, Arvind
Fisher, Liesl G.
Wu, Gang
Skwish, Stephen
Michel, Inge M.
Seiler, Steven M.
Dickinson, Kenneth E. J.
Carboxyl and other negatively charged groups were found to be most effective at producing human β3 adrenergic receptor binding selectivity in 1 (BRL 37344) and related compounds. The sulfonic acid analog 7 (EMS-187413) is a novel and potent β3 adrenergic agonist that binds selectively, and thus has an in vitro profile that compares favorably with that of BRL 37344.
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