Kinetic and thermodynamic control of L-threonine aldolase catalyzed reaction and its application to the synthesis of mycestericin D

DOI: 10.1016/0040-4039(96)00430-3

Source and publish data:

Tetrahedron Letters p. 2791 - 2794 (1996)

Update date:2022-09-26

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Authors:

Shibata, Kayoko

Shingu, Kazushi

Vassilev, Vassil P.

Nishide, Kiyoharu

Fujita, Tetsuro

Node, Manabu

Kajimoto, Tetsuya

Wong, Chi-Huey

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Article abstract of DOI:10.1016/0040-4039(96)00430-3

L-Threonine aldolase catalyzes the aldol condensation of γ-benzyloxybutanal and glycine with high erythro/threo selectivity under a kinetically controlled condition. The erythro product was used in the synthesis of mycestericin D, a potent immunosuppressant.

Full text of DOI:10.1016/0040-4039(96)00430-3

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