Diastereoselective synthesis of a taxane precursor

Article abstract of DOI:10.1016/0040-4039(96)00538-2

A highly diastereoselective synthesis of the taxane potential precursor 16 is achieved. An unexpected diastereoselectivity was observed upon condensation of the α-trimethylsiloxyaldehydes 9a or 9b with the cyclohexenyllithium 10. The single diol isomers 13A and 14A exhibiting the required 1β,2α relative configuration are obtained in good yields.