Benzothiazol-2-ylcarboxylic acids with diverse spacers: A novel class of potent, orally active aldose reductase inhibitors

DOI: 10.1016/S0960-894X(97)00287-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1677 - 1682 (1997)

Update date:2022-07-29

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Authors:

Aotsuka, Tomoji

Abe, Naoki

Fukushima, Kanako

Ashizawa, Naoki

Yoshida, Motoyuki

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Article abstract of DOI:10.1016/S0960-894X(97)00287-4

The benzothiazol-2-ylcarboxylic acids, with diverse spacers between the carboxy group and the benzothiazole ring, were synthesized and evaluated for their ability to inhibit aldose reductase (AR) The phenylacetic acids 6 which have a less complex structure than that of existing AR inhibitors were found to be highly potent orally active AR inhibitors.

Full text of DOI:10.1016/S0960-894X(97)00287-4

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