Bioorganic and Medicinal Chemistry Letters p. 1677 - 1682 (1997)
Update date:2022-07-29
Topics:
Aotsuka, Tomoji
Abe, Naoki
Fukushima, Kanako
Ashizawa, Naoki
Yoshida, Motoyuki
The benzothiazol-2-ylcarboxylic acids, with diverse spacers between the carboxy group and the benzothiazole ring, were synthesized and evaluated for their ability to inhibit aldose reductase (AR) The phenylacetic acids 6 which have a less complex structure than that of existing AR inhibitors were found to be highly potent orally active AR inhibitors.
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