Practical enantiospecific synthesis of RPR 111905: A novel Non-peptide substance P antagonist

Article abstract of DOI:10.1016/S0040-4039(96)02017-5

The synthesis of enantiomerically pure RPR 111905 was achieved in twelve steps with an overall yield of 6.9%. The synthetic strategy was based on a Diels-Alder reaction to generate the bicyclio framework and the asymmetry was introduced by resolution.