Syntheses of imidazole-acridine conjugates as ribonuclease A mimics

DOI: 10.1016/0040-4039(96)00843-X

Source and publish data:

Tetrahedron Letters p. 4417 - 4420 (1996)

Update date:2022-07-29

Topics:

Authors:

Lorente, Antonio

Espinosa, Juan Felix

Fernandez-Saiz, Misericordia

Lehn, Jean-Marie

Wilson, W. David

Zhong, Yi Yi

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Article abstract of DOI:10.1016/0040-4039(96)00843-X

As a result of efforts to mimic the activity of RNase A we report the syntheses of two novel molecules 1 and 2 containing imidazole residues conjugated to an acridine, a well known intercalator and as such these molecules simultaneously have substrate recognition and potential catalytic ability. t-RNA cleavage by 1 and 2 is reported.

Full text of DOI:10.1016/0040-4039(96)00843-X

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